When doing remote front page debugging using visual studio 2008 in windows 2003 or windows 2008, one might found the breakpoint in the script cannot be hit. A likely reason is that we need to turn off Internet Explorer Enhanced Security Configuration
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Read the complete post at http://blogs.iis.net/webdevelopertips/archive/2009/03/27/tip-47-did-you-know-that-front-page-script-remote-debugging-requires-turning-off-ie-s-enhanced-security-configuration-in-windows-2003-and-windows-2008.aspx